Endocrine Abstracts

Congenital adrenal hyperplasia (CAH) is due to autosomal recessive genetic defects in enzymes required for cortisol synthesis. Defects in the gene encoding steroid 21-hydroxylase (CYP21A2) account for most CAH cases. In all cases of 21-OHD, obstructed cortisol synthesis prompts ACTH elevations, which, in turn, stimulate adrenal cortical growth and steroidogenic flux. The combination of ACTH elevation and 21-OHD favors the overproduction of adrenal androgens. The 2 main treatme...

Glycoregulation disorders in endocrine are frequently, hormone excess or deficit resulting for impaired metabolism of glucose by different mechanisms.Methods: The study was conducted on 118 patients with hyperthyroidism, acromegaly and hypercortisolism. The inclusion criteria were: patients nondiagnostics that have not followed the treatment with drugs that could induce hyperglycemia (epinephrine, oral contraceptives, glucocorticoids, mineralcorticoids e...

Early sexualisation defines the appearance of any sign of sexual maturation at a younger age than 2 S.D. from the mean, namely <8 years at girls and 9 years at boys. The really precocious puberty is always isosexual, sexuality program runs in line with genetic sex and gonads of the subject. In making her part of the whole system gonadal function: the hypothalamus–pituitary–gonad-receptors, and gonads is fully enabled not only hormonogenetic, both a...

The adrenal glands serve as central organs of the endocrine system by producing steroid hormone essential for organismal homeostasis. Mechanisms ensuring proper adrenal homeostasis and function are therefore crucial for maintaining human life. ACTH, released by the pituitary corticotrope, is required for the differentiation of the inner part of the adrenal cortex (the zona fasciculata) and the resultant stimulation of cortisol production. Perturbation of ACTH signaling can lea...

Background: Osilodrostat (potent oral 11β-hydroxylase inhibitor) provided rapid normalisation of mean urinary free cortisol (mUFC) in Cushing’s disease (CD) patients during the 48-week (W) core period of LINC 4 (NCT02697734) and was well tolerated. We report long-term efficacy and safety results from the LINC 4 core and extension phases.Methods: 73 adults with CD and mUFC >1.3 upper limit of normal (ULN) were enrolled. LINC 4 comprised a 12...

Background: Cushing’s disease (CD) is associated with hypercortisolism-induced cardiovascular morbidity and mortality and impaired patient quality of life (QoL). We report long-term effects of osilodrostat (potent 11β-hydroxylase inhibitor) on cardiovascular/metabolic-related risk factors, physical features of hypercortisolism and QoL in CD patients following the core and extension phases of the LINC 4 study (NCT02697734).Methods: LINC 4 compri...